Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adults.

Authors :: Moratto D
Giacomelli M
Chiarini M
Savarè L
Saccani B
Motta M
Timpano S
Poli P
Paghera S
Imberti L
Cannizzo S
Quiros-Roldan E
Marchetti G
Badolato R
Source :: European journal of immunology [Eur J Immunol] 2020 Sep; Vol. 50 (9), pp. 1412-1414. Date of Electronic Publication: 2020 Jul 29.
Publication Year :: 2020
Abstract: Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1β in adults with COVID-19, but not in children. In addition, plasmatic levels of CCL5/RANTES are higher in children and adults with COVID-19, while CXCL9/MIG was only increased in adults. Higher number of activated T cells and expression of IL-12 and CXCL9 suggest prominent Th1 polarization of immune response against SARS-CoV2 in infected adults as compared with children.<br /> (© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

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