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Late mortality in survivors of childhood cancer in Hungary.
- Source :
-
Scientific reports [Sci Rep] 2020 Jul 01; Vol. 10 (1), pp. 10761. Date of Electronic Publication: 2020 Jul 01. - Publication Year :
- 2020
-
Abstract
- The Hungarian Pediatric Oncology Network provides centralized treatment and population-based registration for cases of childhood cancer since 1973. We collected and analized data on late mortality, secondary malignancies and cardiac diseases in survivors (> 5 years) of childhood cancer to evaluate long-term risks. We extracted all solid tumour cases (3,650 followed up for 5-39.3 years, diagnosis: 1973-2008) from the database of the Hungarian Childhood Cancer Registry and checked against the Population Registry. Among the 301 patients who died after 5 years (8.2%) the most common causes of death were progression of primary cancer (52.5%), secondary malignancies (16%) and cardiovascular diseases (8%). Late mortality rates (SMR, total: 35,006 pyrs) showed highly elevated risk of death (SMR: 10.7 95% CI 9-12.4) for the second 5 years of follow up and moderately elevated risk for 10-year survivors (SMR: 3.5 95% CI 3-4.1). Marked differences were detected in the pattern of causes of death between diagnostic groups of primary cancer; with highest risks beyond 10 years for CNS tumours, Hodgkin disease, osteosarcoma and advanced stage neuroblastoma. The longstanding mortality risk for 5-year survivors underlines the need for tailored long-term follow-up and monitoring of late consequences according to the context of different primary diseases of childhood cancer.
- Subjects :
- Adolescent
Adult
Cause of Death
Child
Child, Preschool
Disease Progression
Female
Hodgkin Disease diagnosis
Humans
Hungary epidemiology
Infant
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasms diagnosis
Neoplasms, Second Primary
Neuroblastoma diagnosis
Osteosarcoma diagnosis
Registries
Risk
Treatment Outcome
Young Adult
Cancer Survivors
Hodgkin Disease mortality
Neoplasms mortality
Neuroblastoma mortality
Osteosarcoma mortality
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32612167
- Full Text :
- https://doi.org/10.1038/s41598-020-67444-1