Back to Search Start Over

Comparison of commercial surface-enhanced Raman spectroscopy substrates for the analysis of cocaine.

Authors :
Alder R
Xiao L
Fu S
Source :
Drug testing and analysis [Drug Test Anal] 2021 May; Vol. 13 (5), pp. 944-952. Date of Electronic Publication: 2020 Jul 19.
Publication Year :
2021

Abstract

The use of illicit drugs across the world causes issues for users, healthcare workers and the public. Therefore, rapid and reliable onsite testing methods to detect these drugs are required. In this study, seven commercial surface-enhanced Raman spectroscopy (SERS) substrates A-G were compared for the analysis of cocaine. These substrates were compared using scanning electron microscopy to study the surface structure and Raman spectroscopy and to determine if there was any enhancement of the cocaine bands. Substrate B provided the best enhancement of known cocaine vibrational bands, allowing the detection down to concentrations of 1 ng/mL in standards and 10 ng/mL extracted from the oral fluid. The results showed that SERS is an ideal method for future rapid onsite analysis of illicit drugs in oral fluid. Commercial SERS substrates were compared for the analysis of cocaine. Substrate B provided the best result and was further tested with lower concentrations and extracts from the oral fluid. The application to oral fluid testing could prove useful for future onsite analysis.<br /> (© 2020 John Wiley & Sons, Ltd.)

Details

Language :
English
ISSN :
1942-7611
Volume :
13
Issue :
5
Database :
MEDLINE
Journal :
Drug testing and analysis
Publication Type :
Academic Journal
Accession number :
32627419
Full Text :
https://doi.org/10.1002/dta.2894