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Modulation of antibiotic resistance by the essential oil of Ocimum gratissimum L. in association with light-emitting diodes (LED) lights.
- Source :
-
Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2020 Nov 26; Vol. 75 (11-12), pp. 377-387. - Publication Year :
- 2020
-
Abstract
- This study aimed to evaluate the antibacterial and antibiotic-enhancing effects of the essential oil obtained from Ocimum gratissimum L. (OEOg) alone or in association with light-emitting diodes (LED) lights. The essential oil was obtained by hydrodistillation and its chemical composition analysed by gas chromatography coupled to mass spectrometry. The antibacterial and antibiotic-enhancing activities against multiresistant strains of Staphylococcus aureus and Escherichia coli were evaluated by the gaseous contact method. The analysis of the photoinductive effect on the antibacterial activity of the OEOg and antibiotics was assessed through exposure to different LED lights (red, blue and yellow). The phytochemical analysis identified five compounds, including eugenol, as the major constituent. The OEOg caused a significant inhibition of the halo, indicating a direct antibacterial effect. Exposure to the LED lights significantly enhanced the activity of the OEOg against E. coli. On the other hand, the action of the essential oil against S. aureus was enhanced by exposure to both blue and yellow lights. The effects of LED light exposure on the activity of conventional antibiotics varied significantly according to the drug and the bacterial strain. However, most combinations of LED lights and the OEOg presented synergistic effects against resistant bacterial strains, indicating enhanced antibacterial activity. Thus, these in vitro findings suggest that both OEOg and LED lights have promising antibacterial effects. Nevertheless, further research is required to evaluate in vivo the potential of these therapies for the treatment of infectious skin diseases.
- Subjects :
- Anti-Bacterial Agents pharmacology
Anti-Infective Agents chemistry
Drug Resistance, Bacterial drug effects
Drug Synergism
Escherichia coli drug effects
Escherichia coli pathogenicity
Gas Chromatography-Mass Spectrometry
Humans
Microbial Sensitivity Tests
Oils, Volatile chemistry
Staphylococcus aureus drug effects
Staphylococcus aureus pathogenicity
Anti-Infective Agents pharmacology
Drug Resistance, Bacterial genetics
Ocimum chemistry
Oils, Volatile pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1865-7125
- Volume :
- 75
- Issue :
- 11-12
- Database :
- MEDLINE
- Journal :
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Publication Type :
- Academic Journal
- Accession number :
- 32628640
- Full Text :
- https://doi.org/10.1515/znc-2020-0034