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Modulation of antibiotic resistance by the essential oil of Ocimum gratissimum L. in association with light-emitting diodes (LED) lights.

Authors :
Silva Leandro MKDN
Rocha JE
Bezerra CF
Freitas PR
Feitosa JHF
Bezerra VB
Barros RO
Leandro LMG
Aguiar JJDS
Pereira PS
Christofoli M
Ribeiro-Filho J
Iriti M
Coutinho HDM
Matias EFF
Source :
Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2020 Nov 26; Vol. 75 (11-12), pp. 377-387.
Publication Year :
2020

Abstract

This study aimed to evaluate the antibacterial and antibiotic-enhancing effects of the essential oil obtained from Ocimum gratissimum L. (OEOg) alone or in association with light-emitting diodes (LED) lights. The essential oil was obtained by hydrodistillation and its chemical composition analysed by gas chromatography coupled to mass spectrometry. The antibacterial and antibiotic-enhancing activities against multiresistant strains of Staphylococcus aureus and Escherichia coli were evaluated by the gaseous contact method. The analysis of the photoinductive effect on the antibacterial activity of the OEOg and antibiotics was assessed through exposure to different LED lights (red, blue and yellow). The phytochemical analysis identified five compounds, including eugenol, as the major constituent. The OEOg caused a significant inhibition of the halo, indicating a direct antibacterial effect. Exposure to the LED lights significantly enhanced the activity of the OEOg against E. coli. On the other hand, the action of the essential oil against S. aureus was enhanced by exposure to both blue and yellow lights. The effects of LED light exposure on the activity of conventional antibiotics varied significantly according to the drug and the bacterial strain. However, most combinations of LED lights and the OEOg presented synergistic effects against resistant bacterial strains, indicating enhanced antibacterial activity. Thus, these in vitro findings suggest that both OEOg and LED lights have promising antibacterial effects. Nevertheless, further research is required to evaluate in vivo the potential of these therapies for the treatment of infectious skin diseases.

Details

Language :
English
ISSN :
1865-7125
Volume :
75
Issue :
11-12
Database :
MEDLINE
Journal :
Zeitschrift fur Naturforschung. C, Journal of biosciences
Publication Type :
Academic Journal
Accession number :
32628640
Full Text :
https://doi.org/10.1515/znc-2020-0034