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IL18-containing 5-gene signature distinguishes histologically identical dermatomyositis and lupus erythematosus skin lesions.
- Source :
-
JCI insight [JCI Insight] 2020 Aug 20; Vol. 5 (16). Date of Electronic Publication: 2020 Aug 20. - Publication Year :
- 2020
-
Abstract
- Skin lesions in dermatomyositis (DM) are common, are frequently refractory, and have prognostic significance. Histologically, DM lesions appear similar to cutaneous lupus erythematosus (CLE) lesions and frequently cannot be differentiated. We thus compared the transcriptional profile of DM biopsies with CLE lesions to identify unique features. Type I IFN signaling, including IFN-κ upregulation, was a common pathway in both DM and CLE; however, CLE also exhibited other inflammatory pathways. Notably, DM lesions could be distinguished from CLE by a 5-gene biomarker panel that included IL18 upregulation. Using single-cell RNA-sequencing, we further identified keratinocytes as the main source of increased IL-18 in DM skin. This study identifies a potentially novel molecular signature, with significant clinical implications for differentiating DM from CLE lesions, and highlights the potential role for IL-18 in the pathophysiology of DM skin disease.
- Subjects :
- Biopsy
Cohort Studies
Cornified Envelope Proline-Rich Proteins genetics
Dermatomyositis metabolism
Dermatomyositis pathology
Female
Humans
Interferons genetics
Interferons metabolism
Keratins, Type II genetics
Lupus Erythematosus, Cutaneous metabolism
Lupus Erythematosus, Cutaneous pathology
Male
Middle Aged
Myxovirus Resistance Proteins metabolism
Transcriptome
Tropomyosin genetics
Dermatomyositis genetics
Interleukin-18 genetics
Lupus Erythematosus, Cutaneous genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2379-3708
- Volume :
- 5
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- JCI insight
- Publication Type :
- Academic Journal
- Accession number :
- 32644977
- Full Text :
- https://doi.org/10.1172/jci.insight.139558