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Short-term efficacy of ORS formulation and propranolol regimen in children with POTS.
Short-term efficacy of ORS formulation and propranolol regimen in children with POTS.
- Source :
-
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2020 Aug; Vol. 27 (6), pp. 328-332. Date of Electronic Publication: 2020 Jul 07. - Publication Year :
- 2020
-
Abstract
- Background: To evaluate the short-term effectiveness of reduced-osmolarity oral rehydration salt formulation (ORS) and propranolol in children diagnosed with postural orthostatic tachycardia syndrome (POTS) in head-up tilt testing (HUTT).<br />Methods: Children were admitted with symptoms of orthostatic intolerance (OI) occurring in a standing position and disappearing in the supine position. Patients with heart rate increments of ≥40bpm and symptoms of OI constituted the pediatric POTS group in HUTT. A total of 70 pediatric patients with POTS were included in the study. POTS patients were divided into two groups based on whether they were prescribed reduced-osmolarity ORS and propranolol or not. The study group comprised patients on a regimen of reduced-osmolarity ORS and propranolol (n=34), while the control group comprised patients who were not prescribed any medication (n=36). The frequency of symptoms and standardized symptom scores were analyzed before and after 3 months of treatment in both groups.<br />Results: The post-treatment frequency of syncopal attacks was significantly reduced in both groups (P<0.01 for both groups), but the post-treatment standardized symptom scores were significantly reduced in the pediatric study group compared with the control group (P<0.01).<br />Conclusion: The frequency of syncopal attacks was significantly reduced and the symptom scores for OI were improved in the study group. The improvement in OI symptom scores was better in the treatment group than in the control group. The control group symptoms persisted and caused extreme difficulty in their daily activities. In view of its clinical efficacy, we strongly advocate the use of combined treatment of reduced-osmolarity ORS and low-dose propranolol in pediatric patients with POTS.<br /> (Copyright © 2020 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adolescent
Child
Female
Humans
Male
Combined Modality Therapy
Follow-Up Studies
Prospective Studies
Treatment Outcome
Adrenergic beta-Antagonists therapeutic use
Electrolytes therapeutic use
Fluid Therapy methods
Postural Orthostatic Tachycardia Syndrome therapy
Propranolol therapeutic use
Rehydration Solutions therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1769-664X
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
- Publication Type :
- Academic Journal
- Accession number :
- 32651146
- Full Text :
- https://doi.org/10.1016/j.arcped.2020.06.001