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Circulating miRNAs as Biomarkers in Aggressive B Cell Lymphomas.
- Source :
-
Trends in cancer [Trends Cancer] 2020 Nov; Vol. 6 (11), pp. 910-923. Date of Electronic Publication: 2020 Jul 11. - Publication Year :
- 2020
-
Abstract
- B cell lymphomas are heterogeneous malignancies of hematological origin with vastly different biology and clinical outcomes. Histopathology of tissue biopsies and image-based assessment guide clinical decisions. Given that tissue biopsies cannot be frequently repeated and will not inform on systemic responses to the treatment, more accessible biomarkers, such as circulating miRNAs, are considered. Aberrant miRNA expression in lymphoma tissues and ongoing immune reactions may lead to miRNA alterations in circulation. miRNAs bound to extracellular vesicles (EVs) are of interest because of their role in intercellular communication and organ crosstalk. Herein, we highlight the role of miRNAs and EVs in B cell lymphomagenesis and explain how circulating miRNAs may be turned into robust liquid biopsy tests for aggressive B cell lymphoma.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Biomarkers, Tumor metabolism
Carcinogenesis genetics
Circulating MicroRNA metabolism
Gene Expression Regulation, Neoplastic
Humans
Liquid Biopsy methods
Lymphoma, B-Cell blood
Lymphoma, B-Cell genetics
Reproducibility of Results
Specimen Handling methods
Biomarkers, Tumor blood
Circulating MicroRNA blood
Extracellular Vesicles metabolism
Lymphoma, B-Cell diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 6
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32660885
- Full Text :
- https://doi.org/10.1016/j.trecan.2020.06.003