The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of multiple myeloma.

Outcomes in multiple myeloma (MM) have improved dramatically in the last two decades with the advent of novel therapies including immunomodulatory agents (IMiDs), proteasome inhibitors and monoclonal antibodies. In recent years, immunotherapy for the treatment of MM has advanced rapidly, with the approval of new targeted agents and monoclonal antibodies directed against myeloma cell-surface antigens, as well as maturing data from late stage trials of chimeric antigen receptor CAR T cells. Therapies that engage the immune system to treat myeloma offer significant clinical benefits with durable responses and manageable toxicity profiles, however, the appropriate use of these immunotherapy agents can present unique challenges for practicing physicians. Therefore, the Society for Immunotherapy of Cancer convened an expert panel, which met to consider the current role of approved and emerging immunotherapy agents in MM and provide guidance to the oncology community by developing consensus recommendations. As immunotherapy evolves as a therapeutic option for the treatment of MM, these guidelines will be updated.
Competing Interests: Competing interests: JA: consultant with SWOG, NCI, CIBMTR, received honoraria from Patient Power, Celgene and Janssen, board member Patient Empowerment Network, advisor for Myeloma Crowd; DEA: advisory board for Celgene, Juno, Partners Tx, Karyopharm and Bristol-Myers Squibb, research support from Celgene and Pharmacyclics, consulting for Janssen, Parexel and Takeda; JGB: contracted research for AbbVie, Amgen, Acetylon, Bluebird, Bristol-Myers Squibb, Celgene, Celularity, Constellation, CURIS, EMD Sorono, Genentech, Glenmark, Janssen, Kesios, Eli Lilly, Novartis, Poseida, Sanofi, Takeda, Teva and Vivolux, consulting fees for Takeda, Bristol-Myers Squibb, Karyopharm, CRISPR Therapeutics, Celgene, Kite Pharma, Legend, Servier, Janssen, Amgen, BioClinica, Prothena; IMB: founder and shareholder Wind MIL Therapeutics, consulting for Celgene and Bristol-Myers Squibb; AC: research funding from Pharmacyclics, Seattle Genetics and Janssen; advisory board for Janssen, consulting for Seattle Genetics, Janssen, Karyopharm, Sanofi and OncoPeptides; ADC: consulting for Celgene, Takeda, Janssen, GlaxoSmithKline, Kite Pharma, Oncopeptides, Seattle Genetics, contracted research for Novartis; MD: advisory board for Amgen, Kite, Celgene, Janssen, Lava Therapeutics and Roche; LG: speaker’s bureau for Genetech, IMF Nurse Leadership Board; DG: patents and royalties from Juno Therapeutics and Celgene, advisory board for Juno Therapeutics, Celgene, GSK, Seattle Genetics; AK: consulting for Celgene, advisory board for Sutro and 2Predicta, speaker for Celgene, Amgen and Takeda, stockholder Celgene, grant support from Janssen; YL: research funding from Kite/Gilead, Celgene, BlueBird Bio, Merck, Takeda and Janssen, advisory board for Kite/Gilead, Celgene, Bluebird Bio, Juno, Novartis and Janssen; EM: consulting for Adaptive Biotechnologies, Janssen, Celgene and Sanofi, contracted research for Sanofi, Quest Diagnostics and Merck; NCM: consulting for AbbVie, Adaptive, Amgen, Celgene, Janssen, Takeda, Oncopep, owner and stakeholder Oncopep; AKN: honorarium for participation inadvisory board for Amgen, Celgene, Takeda, Adaptive Janssen, GSK and Spectrum Pharmaceuticals; NS: advisor for Amgen, Bristol-Myers Squibb, Kite, Nkarta, Nektar, Oncopeptides, Karyopharm, Seattle Genetics, Indapta Therapeutics, Surface Oncology and Precision Biosciences, stock owenership Indapta Therapeutics; ELS: patents and royalties Juno and Celgene, consulting for Juno, Celgene, Fate Therapeutics and Precision Biosciences; RV: consulting for Celgene, Bristol-Myers Squibb, Sanofi, Takeda, Genentech, GSK, Securbio and Karyopharm, contracted research for Takeda, Celgen and Bristol-Myers Squibb. KG, APP have nothing to disclose. SITC Staff: AK, LL, RL, and SMW have nothing to disclose.
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