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DASH-type cryptochromes - solved and open questions.
- Source :
-
Biological chemistry [Biol Chem] 2020 Nov 26; Vol. 401 (12), pp. 1487-1493. - Publication Year :
- 2020
-
Abstract
- Drosophila, Arabidopsis, Synechocystis, human (DASH)-type cryptochromes (cry-DASHs) form one subclade of the cryptochrome/photolyase family (CPF). CPF members are flavoproteins that act as DNA-repair enzymes (DNA-photolyases), or as ultraviolet(UV)-A/blue light photoreceptors (cryptochromes). In mammals, cryptochromes are essential components of the circadian clock feed-back loop. Cry-DASHs are present in almost all major taxa and were initially considered as photoreceptors. Later studies demonstrated DNA-repair activity that was, however, restricted to UV-lesions in single-stranded DNA. Very recent studies, particularly on microbial organisms, substantiated photoreceptor functions of cry-DASHs suggesting that they could be transitions between photolyases and cryptochromes.
Details
- Language :
- English
- ISSN :
- 1437-4315
- Volume :
- 401
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biological chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32663167
- Full Text :
- https://doi.org/10.1515/hsz-2020-0182