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Effects of protein kinase inhibitors on growth factor-stimulated DNA synthesis in cultured rat vascular smooth muscle cells.
- Source :
-
Atherosclerosis [Atherosclerosis] 1988 Dec; Vol. 74 (3), pp. 227-30. - Publication Year :
- 1988
-
Abstract
- The effects of H-7 and ML-9, inhibitors of protein kinase C and myosin light-chain kinase, respectively, on DNA synthesis stimulated by platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) were studied in cultured rat vascular smooth muscle cells (VSMC). H-7 and ML-9 significantly inhibited PDGF-stimulated DNA synthesis in lower concentrations, while both compounds were only effective in inhibiting EGF-induced DNA synthesis in higher concentrations. These data suggest that protein kinase C and myosin light-chain kinase activated by PDGF play a more important role in cell proliferation of VSMC than EGF.
- Subjects :
- Animals
Cells, Cultured
Male
Myosin-Light-Chain Kinase antagonists & inhibitors
Protein Kinase C antagonists & inhibitors
Rats
Rats, Inbred Strains
DNA biosynthesis
Epidermal Growth Factor physiology
Muscle, Smooth, Vascular cytology
Myosin-Light-Chain Kinase pharmacology
Platelet-Derived Growth Factor physiology
Protein Kinase C pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9150
- Volume :
- 74
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 3266471
- Full Text :
- https://doi.org/10.1016/0021-9150(88)90241-9