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A new metabolite of diclofenac sodium in human plasma.
- Source :
-
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 1988 Oct; Vol. 18 (10), pp. 1191-7. - Publication Year :
- 1988
-
Abstract
- 1. Among the phenolic metabolites of diclofenac in human plasma, an unknown compound (metabolite VI) was detected by h.p.l.c. and g.c. methods. This was also found in baboon plasma. 2. Metabolite VI was identified as 3'-hydroxy-4'-methoxy diclofenac by mass and n.m.r. spectroscopic analysis. Comparison with synthetic reference compound confirmed its structure. 3. In plasma, metabolite VI persists much longer than do unchanged diclofenac and the other phenolic metabolites. In urine, metabolite VI and its conjugates are excreted in trace amounts only. 4. A synthetic sample of metabolite VI was shown to be virtually inactive in animal models of inflammation and pain.
- Subjects :
- Adult
Animals
Biotransformation
Cattle
Chemical Phenomena
Chemistry
Diclofenac pharmacology
Gas Chromatography-Mass Spectrometry
Humans
Inflammation drug therapy
Male
Pain drug therapy
Papio
Prostaglandins biosynthesis
Rats
Rats, Inbred Lew
Diclofenac analogs & derivatives
Diclofenac pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0049-8254
- Volume :
- 18
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Xenobiotica; the fate of foreign compounds in biological systems
- Publication Type :
- Academic Journal
- Accession number :
- 3266538
- Full Text :
- https://doi.org/10.3109/00498258809042242