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Altered mitochondrial trafficking as a novel mechanism of cancer metastasis.

Authors :
Furnish M
Caino MC
Source :
Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2020 Feb; Vol. 3 (1), pp. e1157. Date of Electronic Publication: 2019 Feb 14.
Publication Year :
2020

Abstract

Background: Mammalian cells must constantly reprogram the distribution of mitochondria in order to meet the local demands for energy, calcium, redox balance, and other mitochondrial functions. Mitochondrial localization inside the cell is a result of a combination of movement along the microtubule tracks plus anchoring to actin filaments.<br />Recent Findings: Recent advances show that subcellular distribution of mitochondria can regulate tumor cell growth, proliferation/motility plasticity, metastatic competence, and therapy responses in tumors. In this review, we discuss our current understanding of the mechanisms by which mitochondrial subcellular distribution is regulated in tumor cells.<br />Conclusions: Mitochondrial trafficking is dysregulated in tumors. Accumulation of mitochondria at the leading edge of the cell supports energy expensive processes of focal adhesion dynamics, cell membrane dynamics, migration, and invasion.<br /> (© 2019 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
2573-8348
Volume :
3
Issue :
1
Database :
MEDLINE
Journal :
Cancer reports (Hoboken, N.J.)
Publication Type :
Academic Journal
Accession number :
32671955
Full Text :
https://doi.org/10.1002/cnr2.1157