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Phenolic profiles, antioxidant, antiproliferative, and hypoglycemic activities of Ehretia macrophyla Wall. (EMW) fruit.
- Source :
-
Journal of food science [J Food Sci] 2020 Jul; Vol. 85 (7), pp. 2177-2185. Date of Electronic Publication: 2020 Jun 11. - Publication Year :
- 2020
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Abstract
- Phenolic profiles, antioxidant, antiproliferative, and hypoglycemic activities of the whole Ehretia macrophylla Wall. (EMW) fruit were investigated in the present study. Catechin (CE), o-methoxy benzoic acid (o-MBA), and rosmarinic acid (RA) were the predominant phenolics in free extract, while CE, vanillic acid (VA), and o-MBA were for bound extract. These extracts exhibited potential antioxidant capacity measured by peroxyl radical scavenging capacity (PSC), oxygen radical absorbance capacity (ORAC), and cellular antioxidant activity (CAA) assays. This fruit also possessed dose-dependently antiproliferative activity, and this may be due to the synergistic and additive effects of individual phenolics. Furthermore, EMW fruit showed favorable hypoglycemic activity via inhibition of activities of α-glucosidase and α-amylase, enhancement of glucose consumption, glycogen accumulation, and glycogen synthase 2 (GYS2) activity, and downregulation of activities of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK). Therefore, EMW fruit has the potential as an ingredient of functional foods to improve human health and shows promising applications with additional health and economical benefits. PRACTICAL APPLICATION: EMW fruit is a plant-based food rich in natural phenolic compounds, which suggesting its potential bioactivities for humans such as antioxidant, antiproliferative, and hypoglycemic activities. Our findings would provide a logical strategy to promote the comprehensive utilization of phenolics in EMW fruit with both health and economical benefits.<br /> (© 2020 Institute of Food Technologists®.)
- Subjects :
- Antioxidants pharmacology
Cell Line
Cell Proliferation drug effects
Fruit chemistry
Glycoside Hydrolase Inhibitors chemistry
Glycoside Hydrolase Inhibitors pharmacology
Humans
Hypoglycemic Agents pharmacology
Phenols pharmacology
Plant Extracts pharmacology
alpha-Amylases antagonists & inhibitors
alpha-Amylases chemistry
alpha-Glucosidases chemistry
Antioxidants chemistry
Boraginaceae chemistry
Hypoglycemic Agents chemistry
Phenols chemistry
Plant Extracts chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1750-3841
- Volume :
- 85
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of food science
- Publication Type :
- Academic Journal
- Accession number :
- 32672871
- Full Text :
- https://doi.org/10.1111/1750-3841.15185