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HYR-2 plays an anti-lung cancer role by regulating PD-L1 and Akkermansia muciniphila.
- Source :
-
Pharmacological research [Pharmacol Res] 2020 Oct; Vol. 160, pp. 105086. Date of Electronic Publication: 2020 Jul 17. - Publication Year :
- 2020
-
Abstract
- Traditional Chinese medicine (TCM) plays a vital part in cancer treatment due to its unique superiority. Huoxue Yiqi Recipe-2 (HYR-2) was supposed to have therapeutic effect on lung cancer, which came from Ze Qi Decoction in one of the four great classics of TCM called "Synopsis of Prescriptions of the Golden Chamber". Network pharmacology demonstrated that the targets of active components from HYR-2 were significantly enriched in the signaling pathways, which were closely associated with non-small cell lung cancer (NSCLC) and programmed death ligand 1 (PD-L1). Then, data about NSCLC was downloaded from Gene Expression Omnibus database (GEO). The Cancer Genome Atlas (TCGA) and DisGeNET was analyzed by bioinformatics, and 214 biomarkers for NSCLC were obtained, containing 14 targets of active components from HYR-2 (which were significantly enriched in the PD-L1 related signaling pathway). In vivo and in vitro experiments showed that HYR and HYR-2 could inhibit the growth of lung cancer and down-regulate the expression of PD-L1, which might be related to the blocking effect of HYR-2 on the PI3K/Akt signaling pathway. Furthermore, HYR-2 promoted the transformation of M2 macrophages into M1 macrophages as well. It is deserved to be mentioned that the level of Akkermansia muciniphila was also significantly elevated by HYR-2, which was believed to enhance the therapeutic effect of PD-L1 antibodies. To sum up, HYR-2 might play an anti-lung cancer effect by down-regulating PD-L1 together with up-regulating Akkermansia muciniphila.<br /> (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- A549 Cells
Akkermansia drug effects
Akkermansia growth & development
Animals
B7-H1 Antigen genetics
B7-H1 Antigen metabolism
Carcinoma, Lewis Lung drug therapy
Carcinoma, Lewis Lung genetics
Carcinoma, Lewis Lung immunology
Carcinoma, Lewis Lung metabolism
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung immunology
Carcinoma, Non-Small-Cell Lung metabolism
Cell Proliferation drug effects
Gene Regulatory Networks
Hep G2 Cells
Humans
Lung Neoplasms genetics
Lung Neoplasms immunology
Lung Neoplasms metabolism
MCF-7 Cells
Macrophages drug effects
Macrophages metabolism
Male
Mice, Inbred C57BL
Phenotype
Protein Interaction Maps
Signal Transduction
Tumor Burden drug effects
B7-H1 Antigen antagonists & inhibitors
Carcinoma, Non-Small-Cell Lung drug therapy
Drugs, Chinese Herbal pharmacology
Immune Checkpoint Inhibitors pharmacology
Lung Neoplasms drug therapy
Medicine, Chinese Traditional
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1186
- Volume :
- 160
- Database :
- MEDLINE
- Journal :
- Pharmacological research
- Publication Type :
- Academic Journal
- Accession number :
- 32687951
- Full Text :
- https://doi.org/10.1016/j.phrs.2020.105086