PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection.

Authors :: Sanchez Arias JC
Wicki-Stordeur LE
Candlish RC
van der Slagt E
Paci I
Rao PPN
MacVicar BA
Swayne LA
Source :: Cell calcium [Cell Calcium] 2020 Sep; Vol. 90, pp. 102253. Date of Electronic Publication: 2020 Jul 13.
Publication Year :: 2020
Abstract: A new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca <superscript>2+</superscript> influx contributing to IL-1beta production independent of purinergic signaling. These novel findings expand our understanding of TNF-alpha-mediated upregulation of IL-1beta with implications for responses to tissue injury and infection.<br /> (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Subjects :: Human Umbilical Vein Endothelial Cells metabolism
Humans
Inflammasomes metabolism
Models, Biological
Signal Transduction
Tumor Necrosis Factor-alpha metabolism
Connexins metabolism
Infections metabolism
Infections pathology
Inflammation metabolism
Inflammation pathology
Nerve Tissue Proteins metabolism

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