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Agarose-based biomaterials for advanced drug delivery.
- Source :
-
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2020 Oct 10; Vol. 326, pp. 523-543. Date of Electronic Publication: 2020 Jul 20. - Publication Year :
- 2020
-
Abstract
- Agarose is a prominent marine polysaccharide representing reversible thermogelling behavior, outstanding mechanical properties, high bioactivity, and switchable chemical reactivity for functionalization. As a result, agarose has received particular attention in the fabrication of advanced delivery systems as sophisticated carriers for therapeutic agents. The ever-growing use of agarose-based biomaterials for drug delivery systems resulted in rapid growth in the number of related publications, however still, a long way should be paved to achieve FDA approval for most of the proposed products. This review aims at a classification of agarose-based biomaterials and their derivatives applicable for controlled/targeted drug delivery purposes. Moreover, it attempts to deal with opportunities and challenges associated with the future developments ahead of agarose-based biomaterials in the realm of advanced drug delivery. Undoubtedly, this class of biomaterials needs further advancement, and a lot of critical questions have yet to be answered.<br />Competing Interests: Declaration of Competing Interest None<br /> (Copyright © 2020. Published by Elsevier B.V.)
- Subjects :
- Hydrogels
Polysaccharides
Sepharose
Biocompatible Materials
Drug Delivery Systems
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4995
- Volume :
- 326
- Database :
- MEDLINE
- Journal :
- Journal of controlled release : official journal of the Controlled Release Society
- Publication Type :
- Academic Journal
- Accession number :
- 32702391
- Full Text :
- https://doi.org/10.1016/j.jconrel.2020.07.028