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Survival analysis in high-grade glioma: the role of salvage surgery.

Authors :
Vargas López AJ
Fernández Carballal C
Valera Melé M
Rodríguez-Boto G
Source :
Neurologia [Neurologia (Engl Ed)] 2020 Jul 21. Date of Electronic Publication: 2020 Jul 21.
Publication Year :
2020
Publisher :
Ahead of Print

Abstract

Objectives: This study addresses the survival of consecutive patients with high-grade gliomas treated at the same institution over a period of 10 years. We analyse the importance of associated factors and the role of salvage surgery at the time of progression.<br />Methods: We retrospectively analysed a series of patients with World Health Organization (WHO) grade III/IV gliomas treated between 2008 and 2017 at Hospital Gregorio Marañón (Madrid, Spain). Clinical, radiological, and anatomical pathology data were obtained from patient clinical histories.<br />Results: Follow-up was completed in 233 patients with HGG. Mean age was 62.2 years. The median survival time was 15.4 months. Of 133 patients (59.6%) who had undergone surgery at the time of diagnosis, 43 (32.3%) underwent salvage surgery at the time of progression. This subgroup presented longer overall survival and survival after progression. Higher Karnofsky Performance Status score at diagnosis, a greater extent of surgical resection, and initial diagnosis of WHO grade III glioma were also associated with longer survival.<br />Conclusions: About one-third of patients with HGG may be eligible for salvage surgery at the time of progression. Salvage surgery in this subgroup of patients was significantly associated with longer survival.<br /> (Copyright © 2020 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.)

Details

Language :
English; Spanish; Castilian
ISSN :
2173-5808
Database :
MEDLINE
Journal :
Neurologia
Publication Type :
Academic Journal
Accession number :
32709508
Full Text :
https://doi.org/10.1016/j.nrl.2020.04.018