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Anti-inflammatory effects of powdered product of Bu Yang Huan Wu decoction: Possible role in protecting against Transient Focal Cerebral Ischemia.
- Source :
-
International journal of medical sciences [Int J Med Sci] 2020 Jul 11; Vol. 17 (12), pp. 1854-1863. Date of Electronic Publication: 2020 Jul 11 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Bu Yang Huan Wu decoction (BYHW) is a traditional Chinese medicine (TCM) that consists of several herbs and has been used in patients with ischemic stroke for centuries. Although powdered formula of BYHW has widely been prescribed in clinic nowadays, evidence-based effectiveness and mechanism of action of BYHW powdered product in stroke remain to be characterized. Adult male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 90 min followed by reperfusion for 24 h (ischemia/reperfusion; I/R) or sham surgery. After I/R, the rats were then given low dose (0.5 g/kg) and high dose (2.5 g/kg) of BYHW or vehicle by oral gavage twice a day for seven consecutive days. The results showed that I/R induced obvious cerebral infarction and neurobehavioral defects, in parallel with histological aberrations and extensive signaling of proinflammatory cytokines, including tumor necrosis factor (TNF-α) and interleukin-6 (IL-6), in the stroke model. Post-I/R treatment with BYHW powdered product significantly reduced the infarct area and ameliorated neurofunctional defects in a dose-dependent manner. The dose dependence was associated with TNF-α downregulation and interleukin-10 (IL-10) induction. In summary, the present findings demonstrated that BYHW powdered product exhibited therapeutic efficacy for experimental stroke and a higher dose treatment may strengthen the effectiveness via inflammatory modulation.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)
- Subjects :
- Animals
Brain Ischemia genetics
Brain Ischemia pathology
Disease Models, Animal
Dose-Response Relationship, Drug
Gene Expression Regulation drug effects
Humans
Inflammation genetics
Inflammation pathology
Interleukin-10 genetics
Interleukin-6 genetics
Ischemic Stroke genetics
Ischemic Stroke pathology
Medicine, Chinese Traditional
Powders pharmacology
Rats
Reperfusion Injury genetics
Reperfusion Injury pathology
Treatment Outcome
Tumor Necrosis Factor-alpha genetics
Brain Ischemia drug therapy
Drugs, Chinese Herbal pharmacology
Inflammation drug therapy
Ischemic Stroke drug therapy
Reperfusion Injury drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1449-1907
- Volume :
- 17
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32714088
- Full Text :
- https://doi.org/10.7150/ijms.46581