Back to Search
Start Over
Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers.
- Source :
-
Gene [Gene] 2020 Nov 15; Vol. 760, pp. 144991. Date of Electronic Publication: 2020 Jul 25. - Publication Year :
- 2020
-
Abstract
- Breast cancer is the most frequently diagnosed cancer in women worldwide. Identifying reliable biomarkers and druggable molecular targets pose to be a significant quest in breast cancer research. p21-activated kinase 1 (PAK1) is a serine/threonine kinase that direct cell motility, cytoskeletal remodelling, and has been shown to function as a downstream regulator for various cancer signalling cascades that promote cell proliferation, apoptosis deregulation and hasten mitotic abnormalities, resulting in tumor formation and progression. The heterogeneity and acquired drug resistance are important factors that challenge the treatment of breast cancer. p21-activated kinase 1 signalling is crucial for activation of the Ras/RAF/MEK/ERK, PI3K/Akt/mTOR and Wnt signalling cascades which regulate cell survival, cell cycle progression, differentiation, and proliferation. A study involving proteogenomics analysis on breast cancer tissues showed the PAK1 as outlier kinase. In addition to this, few outlier molecules were identified specific to subtypes of breast cancer. A few substrates of PAK1 in breast cancer are already known. In this paper, we have discussed a similar approach called Kinase Interacting Substrate Screening (KISS) for the identification of novel oncogenic substrates of p21-activated kinase specific to subtypes of breast cancer. Such high throughput approaches are expected to accelerate the process of identifying novel drug targets and biomarkers.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Apoptosis drug effects
Apoptosis physiology
Breast Neoplasms drug therapy
Breast Neoplasms genetics
Breast Neoplasms pathology
Cell Line, Tumor
Cell Proliferation drug effects
Cell Proliferation physiology
Cell Survival drug effects
Cell Survival physiology
Female
Humans
Signal Transduction
p21-Activated Kinases genetics
Breast Neoplasms metabolism
p21-Activated Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0038
- Volume :
- 760
- Database :
- MEDLINE
- Journal :
- Gene
- Publication Type :
- Academic Journal
- Accession number :
- 32717309
- Full Text :
- https://doi.org/10.1016/j.gene.2020.144991