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Modified glutinous rice starch-chitosan composite films for buccal delivery of hydrophilic drug.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2020 Oct 01; Vol. 245, pp. 116556. Date of Electronic Publication: 2020 Jun 05. - Publication Year :
- 2020
-
Abstract
- The fabrication and characterization of ball-milling modified glutinous rice starch (MGRS):chitosan (CS) composite films were demonstrated. Effect of CS ratios (2:1, 1:1, 1:2 MGRS:CS) on the film properties was investigated. Lidocaine hydrochloride was used as a model hydrophilic drug. ATR-FTIR confirmed hydrogen bond formation between MGRS and CS. XRD indicated an amorphous state of all fabricated films. The uniform and comparable thickness, weight, and drug contents of all fabricated films were obtained. The presence of CS did not affect the mucoadhesiveness of MGRS films. The increase in tensile strength and decreases in elongation and folding endurance were observed with 1:2 MGRS:CS films. The film swelling and drug release decreased with the CS ratio. Drug permeation across porcine mucosa indicated the enhancement effect of CS, whereby the permeation flux of 1:2 MGRS:CS composite increased by 3 folds. In conclusion, the MGRS:CS composite could be useful for buccal delivery of hydrophilic drug.<br />Competing Interests: Declaration of Competing Interest None.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adhesiveness
Administration, Buccal
Animals
Drug Liberation
Esophageal Mucosa drug effects
Esophageal Mucosa metabolism
Hydrogen Bonding
Permeability drug effects
Swine
Tensile Strength
Anesthetics, Local pharmacology
Chitosan chemistry
Drug Carriers chemistry
Hydrophobic and Hydrophilic Interactions
Lidocaine pharmacology
Oryza chemistry
Starch chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 245
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 32718644
- Full Text :
- https://doi.org/10.1016/j.carbpol.2020.116556