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Four pleiotropic loci associated with fat mass and lean mass.
- Source :
-
International journal of obesity (2005) [Int J Obes (Lond)] 2020 Oct; Vol. 44 (10), pp. 2113-2123. Date of Electronic Publication: 2020 Jul 27. - Publication Year :
- 2020
-
Abstract
- Background: Fat mass and lean mass are two biggest components of body mass. Both fat mass and lean mass are under strong genetic determinants and are correlated.<br />Methods: We performed a bivariate genome-wide association meta-analysis of (lean adjusted) leg fat mass and (fat adjusted) leg lean mass in 12,517 subjects from 6 samples, and followed by in silico replication in large-scale UK biobank cohort sample (N = 370 097).<br />Results: We identified four loci that were significant at the genome-wide significance (GWS, α = 5.0 × 10 <superscript>-8</superscript> ) level at the discovery meta-analysis, and successfully replicated in the replication sample: 2q36.3 (rs1024137, p <subscript>discovery</subscript> = 3.32 × 10 <superscript>-8</superscript> , p <subscript>replication</subscript> = 4.07 × 10 <superscript>-13</superscript> ), 5q13.1 (rs4976033, p <subscript>discovery</subscript> = 1.93 × 10 <superscript>-9</superscript> , p <subscript>replication</subscript> = 6.35 × 10 <superscript>-7</superscript> ), 12q24.31 (rs4765528, p <subscript>discovery</subscript> = 7.19 × 10 <superscript>-12</superscript> , p <subscript>replication</subscript> = 1.88 × 10 <superscript>-11</superscript> ) and 18q21.32 (rs371326986, p <subscript>discovery</subscript> = 9.04 × 10 <superscript>-9</superscript> , p <subscript>replication</subscript> = 2.35 × 10 <superscript>-95</superscript> ). The above four pleiotropic loci may play a pleiotropic role for fat mass and lean mass development.<br />Conclusions: Our findings further enhance the understanding of the genetic association between fat mass and lean mass and provide a new theoretical basis for their understanding.
Details
- Language :
- English
- ISSN :
- 1476-5497
- Volume :
- 44
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- International journal of obesity (2005)
- Publication Type :
- Academic Journal
- Accession number :
- 32719433
- Full Text :
- https://doi.org/10.1038/s41366-020-0645-0