Back to Search
Start Over
Erythrocyte n-6 Polyunsaturated Fatty Acids, Gut Microbiota, and Incident Type 2 Diabetes: A Prospective Cohort Study.
- Source :
-
Diabetes care [Diabetes Care] 2020 Oct; Vol. 43 (10), pp. 2435-2443. Date of Electronic Publication: 2020 Jul 28. - Publication Year :
- 2020
-
Abstract
- Objective: To examine the association of erythrocyte n-6 polyunsaturated fatty acid (PUFA) biomarkers with incident type 2 diabetes and explore the potential role of gut microbiota in the association.<br />Research Design and Methods: We evaluated 2,731 participants without type 2 diabetes recruited between 2008 and 2013 in the Guangzhou Nutrition and Health Study (Guangzhou, China). Case subjects with type 2 diabetes were identified with clinical and biochemical information collected at follow-up visits. Using stool samples collected during the follow-up in the subset ( n = 1,591), 16S rRNA profiling was conducted. Using multivariable-adjusted Poisson or linear regression, we examined associations of erythrocyte n-6 PUFA biomarkers with incident type 2 diabetes and diversity and composition of gut microbiota.<br />Results: Over 6.2 years of follow-up, 276 case subjects with type 2 diabetes were identified (risk 0.10). Higher levels of erythrocyte γ-linolenic acid (GLA), but not linoleic or arachidonic acid, were associated with higher type 2 diabetes incidence. Comparing the top to the bottom quartile groups of GLA levels, relative risk was 1.72 (95% CI 1.21, 2.44) adjusted for potential confounders. Baseline GLA was inversely associated with gut microbial richness and diversity (α-diversity, both P < 0.05) during follow-up and significantly associated with microbiota β-diversity ( P = 0.002). α-Diversity acted as a potential mediator in the association between GLA and type 2 diabetes ( P < 0.05). Seven genera ( Butyrivibrio , Blautia , Oscillospira , Odoribacter , S24-7 other , Rikenellaceae other , and Clostridiales other ) were enriched in quartile 1 of GLA and in participants without type 2 diabetes.<br />Conclusions: Relative concentrations of erythrocyte GLA were positively associated with incident type 2 diabetes in a Chinese population and also with gut microbial profiles. These results highlight that gut microbiota may play an important role linking n-6 PUFA metabolism and type 2 diabetes etiology.<br /> (© 2020 by the American Diabetes Association.)
- Subjects :
- Adult
Aged
Arachidonic Acid blood
Biomarkers blood
China epidemiology
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 microbiology
Erythrocytes chemistry
Fatty Acids, Omega-6 analysis
Fatty Acids, Unsaturated analysis
Fatty Acids, Unsaturated blood
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Diabetes Mellitus, Type 2 epidemiology
Erythrocytes metabolism
Fatty Acids, Omega-6 blood
Gastrointestinal Microbiome physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 43
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 32723842
- Full Text :
- https://doi.org/10.2337/dc20-0631