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The Association Between Periodontal Disease and Breast Cancer in a Prospective Cohort Study.
- Source :
-
Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2020 Dec; Vol. 13 (12), pp. 1007-1016. Date of Electronic Publication: 2020 Jul 29. - Publication Year :
- 2020
-
Abstract
- Periodontal disease may be associated with increased breast cancer risk, but studies have not considered invasive breast cancer and ductal carcinoma in situ (DCIS) separately in the same population. We assessed the relationship between periodontal disease and breast cancer in a large prospective cohort study. The Sister Study followed women without prior breast cancer ages 35 to 74 years from 2003 to 2017 ( N = 49,968). Baseline periodontal disease was self-reported, and incident breast cancer was ascertained over a mean follow-up of 9.3 years. We estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazards regression, adjusting for multiple potential confounders, including smoking status. Heterogeneity in risk for invasive breast cancer versus DCIS was also estimated. About 22% of participants reported a history of periodontal disease at baseline. A total of 3,339 incident breast cancers (2,607 invasive breast cancer, 732 DCIS) were identified. There was no clear association between periodontal disease and overall breast cancer risk (HR = 1.02; 95% CI, 0.94-1.11). However, we observed a nonstatistically significant suggestive increased risk of invasive breast cancer (HR = 1.07; 95% CI, 0.97-1.17) and decreased risk of DCIS (HR = 0.86; 95% CI, 0.72-1.04) associated with periodontal disease, with evidence for heterogeneity in the risk associations (relative HR for invasive breast cancer versus DCIS = 1.24; 95% CI, 1.01-1.52). A case-only analysis for etiologic heterogeneity confirmed this difference. We observed no clear association between periodontal disease and overall breast cancer risk. The heterogeneity in risk associations for invasive breast cancer versus DCIS warrants further exploration.<br /> (©2020 American Association for Cancer Research.)
- Subjects :
- Adult
Aged
Breast Neoplasms pathology
Carcinoma, Ductal, Breast pathology
Carcinoma, Intraductal, Noninfiltrating pathology
Female
Follow-Up Studies
Humans
Incidence
Middle Aged
Prognosis
Prospective Studies
Risk Factors
United States epidemiology
Breast Neoplasms epidemiology
Carcinoma, Ductal, Breast epidemiology
Carcinoma, Intraductal, Noninfiltrating epidemiology
Periodontal Diseases physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1940-6215
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cancer prevention research (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 32727823
- Full Text :
- https://doi.org/10.1158/1940-6207.CAPR-20-0018