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Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
- Source :
-
Technology in cancer research & treatment [Technol Cancer Res Treat] 2020 Jan-Dec; Vol. 19, pp. 1533033820945799. - Publication Year :
- 2020
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Abstract
- Glioma is a common type of tumor in human central nervous system, and it is characterized with high mobility and mortality. The prognosis of patients with advanced glioma remains poor. Thus, it is necessary to develop novel therapeutic approaches for the treatment of this disease. Circular RNAs are a group of noncoding RNAs which have been detected in eukaryotic cells. They are tissue-specific and characterized with a more stable structure compared with linear RNAs. Recently, studies have revealed that certain circular RNAs are involved in biological processes such as gene regulation; however, the functions of most circular RNAs remain unknown and require further investigation. Furthermore, circular RNAs can act as "sponges" of its target microRNA, consequently suppressing their activity. Additionally, impaired expression of circular RNAs is reported in different diseases including cancer. In our study, low expression of circular RNA Scm like with 4 Mbt domains 2 was detected in glioma samples. Furthermore, reduced circRNA Scm like with 4 Mbt domains 2 expression was observed in human glioma cell lines compared to normal astrocyte cells. Additionally, overexpression of circRNA Scm like with 4 Mbt domains 2 suppressed the growth and metastasis of glioma cells in vitro . Moreover, microRNA-182-5p could be a downstream molecule of circRNA Scm like with 4 Mbt domains 2. The influenced of microRNA-182-5p-induced proliferation, migration, and invasion of glioma cells could be abrogated by overexpressed circRNA Scm like with 4 Mbt domains 2. In addition, metastasis suppressor 1 was predicted as a novel target of microRNA-182-5p, and its expression was restored by circRNA Scm like with 4 Mbt domains 2. In summary, our findings provided novel insight into the roles of circRNA Scm like with 4 Mbt domains 2 in glioma. More importantly, circRNA Scm like with 4 Mbt domains 2/microRNA-182-5p/metastasis suppressor 1 axis could be a putative therapeutic target for the treatment of patients with glioma.
- Subjects :
- 3' Untranslated Regions
Adult
Aged
Female
Glioma genetics
Glioma metabolism
Humans
Male
Microfilament Proteins metabolism
Middle Aged
Neoplasm Grading
Neoplasm Proteins metabolism
Neoplasm Staging
Tumor Burden
Gene Expression Regulation, Neoplastic
MicroRNAs genetics
Microfilament Proteins genetics
Neoplasm Proteins genetics
RNA, Circular genetics
Repressor Proteins genetics
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1533-0338
- Volume :
- 19
- Database :
- MEDLINE
- Journal :
- Technology in cancer research & treatment
- Publication Type :
- Academic Journal
- Accession number :
- 32729377
- Full Text :
- https://doi.org/10.1177/1533033820945799