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Antimalarial lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma sp.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2020 Oct; Vol. 73 (10), pp. 702-710. Date of Electronic Publication: 2020 Jul 30. - Publication Year :
- 2020
-
Abstract
- Ten previously undescribed lanostane-type triterpenoids (1-10), together with 15 known lanostanes, were isolated from artificially cultivated fruiting bodies of the basidiomycete Ganoderma sp. BCC 21329. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data and by application of the modified Mosher's method. Compounds 1, 3, 5, and 7 showed moderate antimalarial activity (IC <subscript>50</subscript> 3.8-7.6 μg ml <superscript>-1</superscript> ).
- Subjects :
- Antimalarials chemistry
Antimalarials pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Plasmodium falciparum drug effects
Structure-Activity Relationship
Triterpenes chemistry
Triterpenes pharmacology
Antimalarials isolation & purification
Fruiting Bodies, Fungal chemistry
Ganoderma chemistry
Triterpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 73
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 32733078
- Full Text :
- https://doi.org/10.1038/s41429-020-0357-7