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The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran.
- Source :
-
Iranian journal of pathology [Iran J Pathol] 2020 Summer; Vol. 15 (3), pp. 175-181. Date of Electronic Publication: 2020 Apr 21. - Publication Year :
- 2020
-
Abstract
- Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML). Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran.<br />Methods: Survival rates of 42 APL patients with t(15;17)(q22;q12) were assessed. Clinical information was obtained from archived medical records. Statistical analysis was performed by SPSS 18 software using log-ranked test and Kaplan Maier survival analysis.<br />Results: Females and males comprised 49% and 51%, respectively. The mean age at diagnosis was 34.3 ± 14.1 years old. During the study period, 17 demises occurred in males, while this number was 7 in females. The mean survival of patients (month) was 23.22 ± 3.57 (95% CI: 16.21 ± 30.2). The five-year survival rate obtained 30%. Regarding demographic and clinical features, the highest rates of 5-year survival were recorded in patients with 20-35 years old (47.6%), males (51%), white blood cell count <10 × 10 9 /l (48%), and platelet count >140 × 10 9 /l (100%).<br />Conclusion: Younger age, lower WBC count and higher platelet count were significantly associated with longer survival in AML patients with t(15;17)(q22; q12).
Details
- Language :
- English
- ISSN :
- 1735-5303
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Iranian journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 32754212
- Full Text :
- https://doi.org/10.30699/ijp.2020.101417.2007