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Pregnancy and Hymenoptera venom allergy.

Authors :
Bonadonna P
Mauro M
Preziosi D
Pravettoni V
Source :
Current opinion in allergy and clinical immunology [Curr Opin Allergy Clin Immunol] 2020 Oct; Vol. 20 (5), pp. 465-469.
Publication Year :
2020

Abstract

Purpose of Review: To evaluate the indication to perform venom immunotherapy (VIT) during pregnancy considering the risks of adverse events during the build-up phase or the maintenance phase and analyzing specific articles and guidelines on VIT.<br />Recent Findings: Only few studies treat this argument and literature only counts one recent study on the topic, whereas recent guidelines state the behavior to keep in pregnancy.<br />Summary: Hymenoptera venom allergy (HVA) affects about 7.5% of the European population. VIT is the only effective disease-modifying treatment for patients presenting anaphylactic reactions. VIT counts several mechanisms of action, with the increase of IgG1 and IgG4 and a cytokine impairment inducing a Th2-Th1 shift. Pregnancy is a health condition where a Th2 profile is required to prevent fetal rejection, so VIT could be a problem for the fetus when started during pregnancy.

Details

Language :
English
ISSN :
1473-6322
Volume :
20
Issue :
5
Database :
MEDLINE
Journal :
Current opinion in allergy and clinical immunology
Publication Type :
Academic Journal
Accession number :
32769711
Full Text :
https://doi.org/10.1097/ACI.0000000000000681