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Electrohydrodynamic Sprayable Amphiphilic Polysaccharide-Clasped Nanoscale Self-Assembly for In Vivo Imaging.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2020 Sep 02; Vol. 12 (35), pp. 38899-38905. Date of Electronic Publication: 2020 Aug 25. - Publication Year :
- 2020
-
Abstract
- The work presented in this report demonstrates that amphiphilic polysaccharide-clasped self-assembly (Amp-SA) with nanometer size, encapsulating hydrophobic nanoparticles (NPs) can be generated via electrohydrodynamic spraying. It is observed that the formation of hydrophobic NP-encapsulated Amp-SA is dependent on the surface chemistry of NPs. The citrate-coated magnetic NPs (MNPs-Cit) were also prepared and compared. The hydrophobic magnetic NP-encapsulated Amp-SA (Amp-SA-M) exhibited around 2.7-2.8-fold higher values in r <subscript>2</subscript> relaxivity than that of MNPs-Cit. In addition, the resulting Amp-SA-M achieved ∼17.2-fold higher values in r <subscript>2</subscript> / r <subscript>1</subscript> ratios than MNPs-Cit. The enhanced performances in magnetic transverse ( r <subscript>2</subscript> ) relaxivity and r <subscript>2</subscript> / r <subscript>1</subscript> ratio as well as the in vivo behavior of Amp-SA-M suggest the potential of Amp-SA-M as a promising MRI nanoprobe. This approach based on the nature-originated amphiphilic biopolymers may provide a novel insight into electrohydrodynamic techniques that have the ability to create various nanostructures, encapsulating high-quality hydrophobic nanomaterials for applications in diverse biotechnology.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 12
- Issue :
- 35
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 32805844
- Full Text :
- https://doi.org/10.1021/acsami.0c07473