Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico-biological parameters.

Authors :: Gurnari C
Breccia M
Di Giuliano F
Scalzulli E
Divona M
Piciocchi A
Cicconi L
De Bellis E
Venditti A
Del Principe MI
Arcese W
Lo-Coco F
Garaci F
Voso MT
Source :: British journal of haematology [Br J Haematol] 2021 Apr; Vol. 193 (1), pp. 129-132. Date of Electronic Publication: 2020 Aug 10.
Publication Year :: 2021
Abstract: Acute promyelocytic leukaemia (APL) represents a modern success of precision medicine. However, fatalities occurring within the first 30 days of induction treatment, in particular intracranial haemorrhage (ICH), remain the main causes of death. We studied the clinico-biological characteristics of 13 patients with APL who experienced ICH. Compared to 85 patients without this complication, patients with ICH were older and more frequently had high-risk APL. Moreover, positivity for the 'swirl' sign at neuroradiological imaging and hydrocephalus were predictors of a fatal outcome, together with lower fibrinogen, prolonged international normalized ratio (INR) and higher lactate dehydrogenase levels.<br /> (© 2020 British Society for Haematology and John Wiley & Sons Ltd.)

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