FKBP-related ncRNA-mRNA axis in breast cancer.

Authors :: Xiong H
Chen Z
Chen W
Li Q
Lin B
Jia Y
Source :: Genomics [Genomics] 2020 Nov; Vol. 112 (6), pp. 4595-4607. Date of Electronic Publication: 2020 Aug 16.
Publication Year :: 2020
Abstract: Breast cancer (BC) is a disease with morbidity ranking the first of women worldwidely. In current study, 11 DE-miRNAs, consisting of four FKBP4 related DE-miRNAs and seven FKBP5 related DE-miRNAs, were screened. Four hundred and eighty two predicted lncRNAs were found for DE-miRNAs. Then, expression and prognostic results of nine of top 20 lncRNAs of BC were significantly identified. LINC00662 and LINC00963 expression were significantly associated with patients' overall survival (OS). Then, nine potential upstream transcription factors were identified in motifs of DE-miRNAs. Three hundred and twenty target genes were identified for GO annotation and KEGG pathway analysis, which were mainly enriched in cysteine-type endopeptidase activity involved in apoptotic process. Construction and analysis in PPI network showed that RAB7A was selected as a hub gene with the topest connectivity scores. Differential expression analysis of nine in top ten hub genes of BC were significantly identified. RAB7A and ARRB1 expression were significantly related with BC patients' OS.<br /> (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)