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Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant.
- Source :
-
BMC neurology [BMC Neurol] 2020 Aug 19; Vol. 20 (1), pp. 308. Date of Electronic Publication: 2020 Aug 19. - Publication Year :
- 2020
-
Abstract
- Background: The aim of this study was to investigate the hemorrhgic sites and collateral vessels in hemorrhagic MMD with the p.R4810K variant.<br />Methods: Hemorrhage sites were classified as either anterior or posterior. Collateral vessels were classified into three subtypes according to origin: lenticulostriate anastomosis, thalamic anastomosis, and choroidal anastomosis. Hemorrhage sites and collateral vessels were compared between patients with wild-type p.R4810K variant (GG) and patients with heterozygous p.R4810K variant (GA) after 1:1 propensity score matching.<br />Results: A total of 130 hemorrhagic MMD patients were included in present study, 21 pairs (42 hemorrhagic hemispheres) were obtained after 1:1 propensity score. In GA group, 16 hemispheres (76.2%) presented anterior hemorrhage, and 5 hemispheres (23.8%) presented with posterior hemorrhage. In GG group, 13 hemispheres (61.9%) presented anterior hemorrhage, and 8 hemispheres (38.1%) presented with posterior hemorrhage. No significant differences were found in hemorrhagic sites between two matched groups (P > 0.05). Of 21 hemispheres in GA group, 10 (47.6%) exhibited lenticulostriate anastomosis, 6 (28.6%) thalamic anastomosis, and 6 (28.6%) choroidal anastomosis. Of 21 hemispheres in GG group, 3 (14.3%) exhibited lenticulostriate anastomosis, 5 (23.8%) thalamic anastomosis, and 9 (42.9%) choroidal anastomosis. There was significant difference in lenticulostriate anastomosis between two matched groups (P = 0.045). After adjustment the age, sex, and PCA involvement, we found that lenticulostriate anastomosis was associated with p.R4810K variant (OR, 5.995; 95% CI, 1.296-27.737; P = 0.022).<br />Conclusion: Lenticulostriate anastomosis might be associated with p.R4810K variant. Whereas hemorrhagic sites, thalamic anastomosis, and choroidal anastomosis might not be associted withp.R4810K variant.
- Subjects :
- Adenosine Triphosphatases genetics
Adult
Basal Ganglia Cerebrovascular Disease genetics
Basal Ganglia Cerebrovascular Disease pathology
Cerebral Angiography
Female
Genetic Variation
Heterozygote
Humans
Male
Moyamoya Disease complications
Ubiquitin-Protein Ligases genetics
Collateral Circulation
Intracranial Hemorrhages genetics
Intracranial Hemorrhages pathology
Moyamoya Disease genetics
Moyamoya Disease pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2377
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC neurology
- Publication Type :
- Academic Journal
- Accession number :
- 32814565
- Full Text :
- https://doi.org/10.1186/s12883-020-01884-0