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Emerging New Diagnostic Modalities and Therapies of Nonalcoholic Fatty Liver Disease.
- Source :
-
Current gastroenterology reports [Curr Gastroenterol Rep] 2020 Aug 19; Vol. 22 (10), pp. 52. Date of Electronic Publication: 2020 Aug 19. - Publication Year :
- 2020
-
Abstract
- Purpose of Review: Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease in both adults and children. In this article, we review recent developments in the screening, diagnosis, and treatment of pediatric NAFLD.<br />Recent Findings: Although alanine aminotransferase (ALT) remains the best screening test for NAFLD in children, and liver biopsy is still required for the diagnosis of nonalcoholic steatohepatitis (NASH), other noninvasive biomarker/imaging studies (MRI-PDFF and VCTE) have emerged as diagnostic methods for pediatric NAFLD. Two large clinical therapeutic trials testing vitamin E, metformin, and cysteamine in pediatric NAFLD yielded mostly inconclusive results. Bariatric surgery has begun to be used in adolescents with severe obesity. An adult phase 2 study using obeticholic acid (OCA) to treat NASH patients with fibrosis showed some positive results. As we continue to await the first FDA-approved therapeutic agent for NASH, lifestyle change remains the main modality of treatment. Newer diagnostic and treatment modalities for pediatric NAFLD continue to be in development under FDA guidance.
- Subjects :
- Adolescent
Alanine Transaminase blood
Antioxidants therapeutic use
Bariatric Surgery
Child
Child, Preschool
Cysteamine therapeutic use
Cystine Depleting Agents therapeutic use
Delayed-Action Preparations therapeutic use
Diet
Humans
Hypoglycemic Agents therapeutic use
Infant
Infant, Newborn
Life Style
Liver Cirrhosis diagnostic imaging
Metformin therapeutic use
Non-alcoholic Fatty Liver Disease etiology
Pediatric Obesity complications
Vitamin E therapeutic use
Non-alcoholic Fatty Liver Disease diagnosis
Non-alcoholic Fatty Liver Disease therapy
Pediatric Obesity therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1534-312X
- Volume :
- 22
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Current gastroenterology reports
- Publication Type :
- Academic Journal
- Accession number :
- 32814993
- Full Text :
- https://doi.org/10.1007/s11894-020-00786-y