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Identification and Structure Elucidation of Epoxyjanthitrems from Lolium perenne Infected with the Endophytic Fungus Epichloƫ festucae var. lolii and Determination of the Tremorgenic and Anti-Insect Activity of Epoxyjanthitrem I.
- Source :
-
Toxins [Toxins (Basel)] 2020 Aug 17; Vol. 12 (8). Date of Electronic Publication: 2020 Aug 17. - Publication Year :
- 2020
-
Abstract
- Epoxyjanthitrems I-IV ( 1 - 4 ) and epoxyjanthitriol ( 5 ) were isolated from seed of perennial ryegrass ( Lolium perenne ) infected with the endophytic fungus Epichloë festucae var. lolii. Although structures for epoxyjanthitrems I-IV have previously been proposed in the literature, this is the first report of a full structural elucidation yielding NMR (Nuclear magnetic resonance) assignments for all five epoxyjanthitrem compounds, and additionally, it is the first isolation of epoxyjanthitriol ( 5 ). Epoxyjanthitrem I induced tremors in mice and gave a dose dependent reduction in weight gain and feeding for porina ( Wiseana cervinata ), a common pasture pest in New Zealand. These data suggest that epoxyjanthitrems are involved in the observed effects of the AR37 endophyte on livestock and insect pests.
Details
- Language :
- English
- ISSN :
- 2072-6651
- Volume :
- 12
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Toxins
- Publication Type :
- Academic Journal
- Accession number :
- 32824608
- Full Text :
- https://doi.org/10.3390/toxins12080526