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Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2.
- Source :
-
The Journal of international medical research [J Int Med Res] 2020 Aug; Vol. 48 (8), pp. 300060520949077. - Publication Year :
- 2020
-
Abstract
- The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 by the World Health Organization. The disease is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). There is limited information on COVID-19, and treatment has so far focused on supportive care and use of repurposed drugs. COVID-19 can be transmitted via person-to-person contact through droplet spread. Some of the recommended precautionary measures to reduce the rate of disease spread include social distancing, good hygiene practices, and avoidance of crowded areas. These measures are effective because the droplets are heavy and can only travel approximately 1 meter in the air, settling quickly on fixed surfaces. Promising strategies to combat SARS-CoV-2 include discovery of therapeutic targets/drugs and vaccines. In this review, we summarize the epidemiology, pathophysiology, and diagnosis of COVID-19. We also address the mechanisms of action of approved repurposed drugs for therapeutic management of the disease.
- Subjects :
- Adenosine Monophosphate analogs & derivatives
Adenosine Monophosphate therapeutic use
Age Factors
Alanine analogs & derivatives
Alanine therapeutic use
Antibodies, Monoclonal, Humanized therapeutic use
Betacoronavirus drug effects
Betacoronavirus genetics
COVID-19 diagnosis
COVID-19 physiopathology
Chloroquine therapeutic use
Communicable Disease Control methods
Coronavirus Infections diagnosis
Coronavirus Infections physiopathology
Drug Repositioning
Humans
Incidence
Personal Protective Equipment supply & distribution
Physical Distancing
Pneumonia, Viral diagnosis
Pneumonia, Viral physiopathology
Quarantine methods
Quarantine organization & administration
SARS-CoV-2
Severity of Illness Index
Survival Analysis
Antiviral Agents therapeutic use
Betacoronavirus pathogenicity
COVID-19 epidemiology
COVID-19 therapy
Communicable Disease Control organization & administration
Coronavirus Infections epidemiology
Coronavirus Infections therapy
Pandemics
Pneumonia, Viral epidemiology
Pneumonia, Viral therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1473-2300
- Volume :
- 48
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 32842818
- Full Text :
- https://doi.org/10.1177/0300060520949077