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Arterial Structure and Stiffness Are Altered in Young Adults Born Preterm.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Oct; Vol. 40 (10), pp. 2548-2556. Date of Electronic Publication: 2020 Aug 27. - Publication Year :
- 2020
-
Abstract
- Objective: Preterm birth has been associated with changes in arterial structure and function. Association with complications occurring during the neonatal period, including bronchopulmonary dysplasia, on vascular outcomes in adulthood is unknown. Approach and Results: We evaluated a cohort of 86 adults born preterm (below 30 weeks of gestation), compared to 85 adults born term, at a mean age of 23 years. We performed ultrasonographic assessment of the dimensions of the ascending aorta, carotid and brachial arteries, and estimated flow-mediated dilation, carotid-femoral pulse wave velocity, augmentation index corrected for heart rate, and carotid intima-media thickness. All analyses were performed with and without adjustment for potential confounding variables, including height, sex, and body mass index. Ascending aorta diameter in diastole was smaller in the preterm group, but carotid and brachial arteries were similar. Carotid and brachial strain, a marker of arterial distensibility, was smaller in the preterm group, while carotid-femoral pulse wave velocity, was similar between groups, indicating similar aortic stiffness. Carotid intima-media thickness, endothelial function flow-mediated dilation, blood nitrite, and nitrate levels were similar between groups. Individuals with bronchopulmonary dysplasia had lower brachial artery strain suggesting long-term association of this neonatal complication with vascular structure. Diastolic blood pressure was higher in the preterm group and was associated with decreased brachial and carotid distensibility.<br />Conclusions: Young adults born preterm display alterations in arterial distensibility that are associated with a history of bronchopulmonary dysplasia.
- Subjects :
- Adolescent
Adult
Age Factors
Aorta diagnostic imaging
Arterial Pressure
Brachial Artery diagnostic imaging
Bronchopulmonary Dysplasia diagnosis
Bronchopulmonary Dysplasia physiopathology
Carotid Arteries diagnostic imaging
Case-Control Studies
Cross-Sectional Studies
Female
Gestational Age
Heart Rate
Humans
Infant, Newborn
Male
Risk Factors
Vascular Diseases diagnostic imaging
Vascular Diseases physiopathology
Young Adult
Aorta physiopathology
Brachial Artery physiopathology
Bronchopulmonary Dysplasia complications
Carotid Arteries physiopathology
Infant, Premature
Vascular Diseases etiology
Vascular Stiffness
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 40
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 32847389
- Full Text :
- https://doi.org/10.1161/ATVBAHA.120.315099