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The Ways of Isolating Neoantigen-Specific T Cells.
- Source :
-
Frontiers in oncology [Front Oncol] 2020 Aug 11; Vol. 10, pp. 1347. Date of Electronic Publication: 2020 Aug 11 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Immunotherapy has revolutionized the standard of care for a range of malignancies. Accumulating evidence suggests that the success of immunotherapy is likely attributable to neoantigen-specific T cells. Thus, adoptive cell therapy with these neoantigen-specific T cells is highly promising. This strategy has proven to successfully elicit tumor regression or even complete remission in metastatic cancer patients. However, a fundamental challenge is to effectively identify and isolate neoantigen-specific T cells or their T cell receptors (TCRs), from either tumor-infiltrating lymphocytes (TILs) or peripheral blood lymphocytes (PBLs), and many methods have been developed to this end. In this review, we focus on the current proposed strategies for identifying and isolating neoantigen-specific T cells.<br /> (Copyright © 2020 Li and Ding.)
Details
- Language :
- English
- ISSN :
- 2234-943X
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- Frontiers in oncology
- Publication Type :
- Academic Journal
- Accession number :
- 32850430
- Full Text :
- https://doi.org/10.3389/fonc.2020.01347