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Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: Clear cell hidradenoma or low-grade mucoepidermoid carcinoma?
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2020 Oct; Vol. 216 (10), pp. 153140. Date of Electronic Publication: 2020 Aug 02. - Publication Year :
- 2020
-
Abstract
- Clear cell hidradenoma (CCH) is an uncommon adnexal tumor usually arising from eccrine glands and commonly seen on the face and the upper extremities. CCH occurring in the breast is extremely rare. Herein we report a case of MAML2-rearranged CCH of breast with a papillary architecture closely mimicking intraductal papilloma, adenomyoepithelioma and low-grade mucoepidermoid carcinoma, thus representing a source of diagnostic confusion. An overview of salient histologic features and immunophenotypes to distinguish CCH and low-grade mucoepidermoid carcinoma is also integrated into the report.<br /> (Copyright © 2020 Elsevier GmbH. All rights reserved.)
- Subjects :
- Acrospiroma diagnosis
Acrospiroma genetics
Acrospiroma pathology
Biomarkers, Tumor genetics
Breast pathology
Breast Neoplasms genetics
Carcinoma, Mucoepidermoid diagnosis
Female
Gene Rearrangement genetics
Humans
Trans-Activators genetics
Transcription Factors genetics
Young Adult
Breast Neoplasms pathology
Carcinoma, Mucoepidermoid pathology
Genetic Predisposition to Disease genetics
Trans-Activators metabolism
Translocation, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 216
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 32853960
- Full Text :
- https://doi.org/10.1016/j.prp.2020.153140