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Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β 6 Upregulation in Colorectal Cancer.
- Source :
-
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Aug 13; Vol. 2020, pp. 8032187. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- The metastatic potential of colorectal cancer (CRC) is intensively promoted by the tumor microenvironment (TME) in a paracrine manner. As a pleiotropic inflammatory cytokine, Interleukin-6 (IL-6) is produced and involved in CRC, the same scenario where integrin α v β 6 also becomes upregulated. However, the relationship between IL-6 and integrin α v β 6 as well as their involvement in the crosstalk between CRC and TME remains largely unclear. In the present study, we demonstrated a positive correlation between the expression of IL-6 and integrin β 6 in CRC samples. The mutually promotive interaction between CRC and TME was further determined by an indirect coculture system. CRC cells could augment the secretion of IL-6 from fibroblasts, which in return induced invasion and integrin β 6 expression of CRC cells. Through the classic IL-6 receptor/STAT-3 signaling pathway, IL-6 mediated the upregulation of integrin β 6, which was involved in the invasion and epithelial-mesenchymal transition of CRC cells induced by IL-6. Taken together, our results reveal a paracrine crosstalk between IL-6 signals originating from the TME and increased the integrin β 6 level of CRC. IL-6 induces CRC invasion via upregulation of integrin β 6 through the IL-6 receptor/STAT-3 signaling pathway. Combined inhibition of IL-6 along with integrin β 6-targeted strategy may indicate new directions for antitumor strategies for CRC.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2020 Qi Sun et al.)
- Subjects :
- Cell Line, Tumor
Female
Fibroblasts metabolism
Humans
Male
Middle Aged
Neoplasm Invasiveness
Receptors, Interleukin-6 metabolism
STAT3 Transcription Factor metabolism
Signal Transduction
Colorectal Neoplasms genetics
Colorectal Neoplasms pathology
Epithelial-Mesenchymal Transition genetics
Gene Expression Regulation, Neoplastic
Integrin beta Chains genetics
Interleukin-6 metabolism
Up-Regulation genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0994
- Volume :
- 2020
- Database :
- MEDLINE
- Journal :
- Oxidative medicine and cellular longevity
- Publication Type :
- Academic Journal
- Accession number :
- 32855767
- Full Text :
- https://doi.org/10.1155/2020/8032187