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Coupling of Laser Ablation and the Liquid Sampling-Atmospheric Pressure Glow Discharge Plasma for Simultaneous, Comprehensive Mapping: Elemental, Molecular, and Spatial Analysis.
- Source :
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Analytical chemistry [Anal Chem] 2020 Sep 15; Vol. 92 (18), pp. 12622-12629. Date of Electronic Publication: 2020 Aug 28. - Publication Year :
- 2020
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Abstract
- The spatial distributions of elemental and molecular species are vital pieces of information for a broad number of applications such as material development and bio/environmental analysis. There is currently no single analytical method that can simultaneously acquire elemental, molecular, and spatial information from a single sample. This paper presents the coupling of an NWR213 laser ablation (LA) system to the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma for combined atomic and molecular (CAM) analysis. The work demonstrates a fundamental balance that must be considered between the extent of fragmentation of molecules and ionization of atoms for CAM analysis. Detailed studies showed that the interelectrode gap to be a critical parameter for controlling the ionization efficiency of atomic and molecular species. Utilizing Design-of-Experiment (DoE) procedures, the discharge current was also found to be a significant parameter to control. Elemental lead, caffeine, and simultaneous lead and caffeine analysis via LA-LS-APGD-MS was made possible through improved understanding of the influence of plasma parameters on the product mass spectra of laser-ablated particles. Finally, a chemical map of elemental lead and molecular caffeine, from lead nitrate and caffeine residues, was generated, demonstrating the comprehensive mapping capabilities of LA-LS-APGD-MS. The practical relevance of the capabilities is demonstrated by mapping glutamic acid from a cryosectioned chicken breast with a thallium spike deposited within the tissue. It is believed that the LA-LS-APGD-MS could be a valuable methodology for the simultaneous mapping of elemental and molecular species from a variety of samples.
- Subjects :
- Mass Spectrometry
Atmospheric Pressure
Lasers
Polymers analysis
Tyrosine analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6882
- Volume :
- 92
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Analytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32856899
- Full Text :
- https://doi.org/10.1021/acs.analchem.0c02677