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The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk.
- Source :
-
Cancer genomics & proteomics [Cancer Genomics Proteomics] 2020 Sep-Oct; Vol. 17 (5), pp. 571-577. - Publication Year :
- 2020
-
Abstract
- Background: The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk.<br />Materials and Methods: ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls.<br />Results: The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed.<br />Conclusion: The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan.<br /> (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Aged
Alleles
Case-Control Studies
Cigarette Smoking adverse effects
Confounding Factors, Epidemiologic
DNA Repair
Female
Genotype
Humans
Lung Neoplasms genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Assessment methods
Risk Assessment statistics & numerical data
Risk Factors
Taiwan epidemiology
Cigarette Smoking epidemiology
DNA-Binding Proteins genetics
Endonucleases genetics
Genetic Predisposition to Disease
Lung Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1790-6245
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer genomics & proteomics
- Publication Type :
- Academic Journal
- Accession number :
- 32859635
- Full Text :
- https://doi.org/10.21873/cgp.20213