Back to Search
Start Over
Immune-microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence.
- Source :
-
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2020 Oct; Vol. 50 (10), pp. 1148-1158. Date of Electronic Publication: 2020 Sep 18. - Publication Year :
- 2020
-
Abstract
- Background: After the Second World War, the population living in the Karelian region was strictly divided by the "iron curtain" between Finland and Russia. This resulted in different lifestyle, standard of living, and exposure to the environment. Allergic manifestations and sensitization to common allergens have been much more common on the Finnish compared to the Russian side.<br />Objective: The remarkable allergy disparity in the Finnish and Russian Karelia calls for immunological explanations.<br />Methods: Young people, aged 15-20 years, in the Finnish (n = 69) and Russian (n = 75) Karelia were studied. The impact of genetic variation on the phenotype was studied by a genome-wide association analysis. Differences in gene expression (transcriptome) were explored from the blood mononuclear cells (PBMC) and related to skin and nasal epithelium microbiota and sensitization.<br />Results: The genotype differences between the Finnish and Russian populations did not explain the allergy gap. The network of gene expression and skin and nasal microbiota was richer and more diverse in the Russian subjects. When the function of 261 differentially expressed genes was explored, innate immunity pathways were suppressed among Russians compared to Finns. Differences in the gene expression paralleled the microbiota disparity. High Acinetobacter abundance in Russians correlated with suppression of innate immune response. High-total IgE was associated with enhanced anti-viral response in the Finnish but not in the Russian subjects.<br />Conclusions and Clinical Relevance: Young populations living in the Finnish and Russian Karelia show marked differences in genome-wide gene expression and host contrasting skin and nasal epithelium microbiota. The rich gene-microbe network in Russians seems to result in a better-balanced innate immunity and associates with low allergy prevalence.<br /> (© 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Age Factors
Female
Finland epidemiology
Gene Regulatory Networks
Genome-Wide Association Study
Host Microbial Interactions
Humans
Hypersensitivity immunology
Hypersensitivity microbiology
Hypersensitivity virology
Immunoglobulin E blood
Leukocytes, Mononuclear immunology
Leukocytes, Mononuclear microbiology
Leukocytes, Mononuclear virology
Male
Nasal Mucosa immunology
Nasal Mucosa microbiology
Nasal Mucosa virology
Polymorphism, Single Nucleotide
Prevalence
Russia epidemiology
Skin immunology
Skin microbiology
Skin virology
Transcriptome
Young Adult
Health Status Disparities
Hypersensitivity epidemiology
Immunity, Innate genetics
Microbiota immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2222
- Volume :
- 50
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 32865840
- Full Text :
- https://doi.org/10.1111/cea.13728