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Allopurinol use and type 2 diabetes incidence among patients with gout: A VA retrospective cohort study.
- Source :
-
Medicine [Medicine (Baltimore)] 2020 Aug 28; Vol. 99 (35), pp. e21675. - Publication Year :
- 2020
-
Abstract
- To assess the impact of allopurinol on diabetes in a retrospective cohort of Veterans' Affairs patients with gout.The New York Harbor VA computerized patient record system was searched to identify patients with an ICD-9 code for gout meeting at least 4 modified 1977 American Rheumatology Association gout diagnostic criteria. Patients were divided into subgroups based on >30 continuous days of allopurinol, versus no allopurinol. New diagnoses of diabetes, defined according to American Diabetes Association diagnostic criteria or clinical documentation explicitly stating a new diagnosis of diabetes, were identified during an observation period from January 1, 2000 through December 31, 2015.Six hundred six gout patients used allopurinol >30 continuous days, and 478 patients never used allopurinol. Over an average 7.9ā±ā4.8 years of follow-up, there was no significant difference in diabetes incidence between the allopurinol and non-allopurinol groups (11.7/1000 person-years vs 10.0/1000 person-years, Pā=ā.27). A lower diabetes incidence in the longest versus shortest quartiles of allopurinol use (6.3 per 1000 person-years vs 19.4 per 1000 person-years, P<.0001) was attributable to longer duration of medical follow-up.In this study, allopurinol use was not associated with decreased diabetes incidence. Prospective studies may further elucidate the relationship between hyperuricemia, gout, xanthine oxidase activity, and diabetes, and the potential impact of gout treatments on diabetes incidence.
- Subjects :
- Aged
Aged, 80 and over
Allopurinol administration & dosage
Colchicine therapeutic use
Female
Follow-Up Studies
Gout Suppressants administration & dosage
Humans
Incidence
Male
Medication Adherence
Middle Aged
New York epidemiology
Retrospective Studies
Time Factors
United States epidemiology
United States Department of Veterans Affairs
Uric Acid blood
Allopurinol therapeutic use
Diabetes Mellitus, Type 2 epidemiology
Gout drug therapy
Gout Suppressants therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 99
- Issue :
- 35
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32871882
- Full Text :
- https://doi.org/10.1097/MD.0000000000021675