Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3- e ][1,2,4]triazine Derivatives.

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3- e ][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3- e ][1,2,4]triazolo[4,3- b ][1,2,4]triazines and pyrazolo[4,3- e ]tetrazolo[1,5- b ][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.
Competing Interests: The authors declare no conflict of interest.