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Transfer of daclatasvir and sofosbuvir's main metabolite, GS-331007, across the human placenta ex vivo.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2020 Dec; Vol. 223 (6), pp. 941-943. Date of Electronic Publication: 2020 Aug 30. - Publication Year :
- 2020
- Subjects :
- Antiviral Agents metabolism
Carbamates metabolism
Female
Hepatitis C drug therapy
Humans
Imidazoles metabolism
Pregnancy
Pregnancy Complications, Infectious drug therapy
Pyrrolidines metabolism
Sofosbuvir metabolism
Sofosbuvir pharmacokinetics
Uridine metabolism
Uridine pharmacokinetics
Valine metabolism
Valine pharmacokinetics
Antiviral Agents pharmacokinetics
Carbamates pharmacokinetics
Imidazoles pharmacokinetics
Maternal-Fetal Exchange
Placenta metabolism
Pyrrolidines pharmacokinetics
Uridine analogs & derivatives
Valine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 223
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Editorial & Opinion
- Accession number :
- 32877661
- Full Text :
- https://doi.org/10.1016/j.ajog.2020.08.107