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Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China.
- Source :
-
Hepatology international [Hepatol Int] 2020 Sep; Vol. 14 (5), pp. 743-753. Date of Electronic Publication: 2020 Sep 03. - Publication Year :
- 2020
-
Abstract
- Background and Aims: The effect of hepatitis B virus (HBV) infection on diabetes has remained unclear. We thus conducted a prospective cohort study to investigate the association between different HBV infection status and new-onset diabetes in a Chinese population.<br />Methods: We enrolled 55,520 participants with HBV serological markers and diabetes free in 2010 in Kailuan cohort. Cox regression models were used to analyze the relationship between different HBV infection status and incidence of diabetes after adjusting different confounders.<br />Results: During an average follow-up of 5.6 years, we identified 6008 incident patients with diabetes. Compared to the participants with hepatitis B surface antigen (HBsAg) negative/hepatitis B surface antibody (anti-HBs) negative/hepatitis B core antibody (anti-HBc) negative, those with chronic HBV infection or with HBsAg negative/anti-HBc positive had a higher risk to occur diabetes. The hazard ratios were 1.18 (95% CI 0.99-1.40, pā=ā0.0588) and 1.22 (95% CI 1.08-1.36, pā=ā0.0009), respectively. The association between chronic HBV infection, anti-HBc positive and diabetes was different between those with different levels of high density lipoprotein cholesterol, blood pressure, body mass index, and age.<br />Conclusion: The individuals with chronic HBV infection or anti-HBc positive may have an increased risk of diabetes, and the association may be modified by the different status of metabolism related variables and age. Effective management of HBV infection may contribute to the reduction of the burden of both hepatitis B and diabetes.
- Subjects :
- Age Factors
Body Mass Index
China epidemiology
Correlation of Data
Female
Humans
Incidence
Male
Metabolism
Middle Aged
Prospective Studies
Risk Assessment
Risk Factors
Cholesterol, HDL blood
Diabetes Mellitus diagnosis
Diabetes Mellitus epidemiology
Hepatitis B Antibodies blood
Hepatitis B, Chronic diagnosis
Hepatitis B, Chronic epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1936-0541
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hepatology international
- Publication Type :
- Academic Journal
- Accession number :
- 32885367
- Full Text :
- https://doi.org/10.1007/s12072-020-10086-2