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Improved Time in Range Over 1 Year Is Associated With Reduced Albuminuria in Individuals With Sensor-Augmented Insulin Pump-Treated Type 1 Diabetes.
- Source :
-
Diabetes care [Diabetes Care] 2020 Nov; Vol. 43 (11), pp. 2882-2885. Date of Electronic Publication: 2020 Sep 04. - Publication Year :
- 2020
-
Abstract
- Objective: To investigate the association between treatment-induced change in continuous glucose monitoring (CGM) time in range (TIR) and albuminuria in persons with type 1 diabetes (T1D) treated with sensor-augmented insulin pumps (SAP).<br />Research Design and Methods: Twenty-six out of 55 participants with albuminuria and multiple daily injection therapy (25% females; median 51 [interquartile range 46-63] years of age; glycated hemoglobin A <subscript>1c</subscript> (HbA <subscript>1c</subscript> ) 75 [68-88] mmol/mol [9.0% (8.4-10.4%)]; and urinary albumin-to-creatinine ratio (UACR) 89 [37-250] mg/g) were in a randomized controlled trial assigned to SAP therapy for 1 year. Anthropometrics, CGM data, and blood and urine samples were collected every 3 months.<br />Results: Mean change (95% CI) in percentage of TIR (%TIR) was 13.2% (6.2; 20.2), in HbA <subscript>1c</subscript> was -14.4 (-17.4; -10.5) mmol/mol (-1.3% [-1.6; -1.0]), and in UACR was -15% (-38; 17) (all P < 0.05). UACR decreased by 19% (10; 28) per 10% increase in %TIR ( P = 0.04), 18% (1; 30) per 10 mmol/mol decrease in HbA <subscript>1c</subscript> ( P = 0.07), and 31% per 10-mmHg decrease in mean arterial pressure ( P < 0.001).<br />Conclusions: In this longitudinal study, treatment-induced increase in %TIR was significantly associated with decrease in albuminuria in T1D.<br /> (© 2020 by the American Diabetes Association.)
- Subjects :
- Blood Glucose analysis
Blood Glucose Self-Monitoring
Creatinine blood
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 urine
Female
Follow-Up Studies
Glycated Hemoglobin analysis
Humans
Longitudinal Studies
Male
Middle Aged
Serum Albumin, Human analysis
Time Factors
Treatment Outcome
Albuminuria complications
Albuminuria drug therapy
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 1 drug therapy
Hypoglycemic Agents administration & dosage
Insulin administration & dosage
Insulin Infusion Systems
Subjects
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 43
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 32887707
- Full Text :
- https://doi.org/10.2337/dc20-0909