Tropane alkaloids from the stem bark of Erythroxylum bezerrae.

Authors :: Brito LSO
Pinto FDCL
de Filho MOM
Rocha DD
Mendoza MFM
Ayala AP
Bezerra BP
Loiola MIB
Canuto KM
Silveira ER
Pessoa ODL
Source :: Phytochemistry [Phytochemistry] 2020 Oct; Vol. 178, pp. 112458. Date of Electronic Publication: 2020 Jul 23.
Publication Year :: 2020
Abstract: Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC <subscript>50</subscript> values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)