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The potential utility of GATA binding protein 3 for diagnosis of malignant pleural mesotheliomas.
- Source :
-
Human pathology [Hum Pathol] 2020 Nov; Vol. 105, pp. 1-8. Date of Electronic Publication: 2020 Sep 02. - Publication Year :
- 2020
-
Abstract
- Malignant pleural mesothelioma is associated with asbestos exposure and poor outcomes. The usefulness of immunohistochemistry for diagnosis of sarcomatoid mesothelioma, especially the desmoplastic type, is limited, and more effective markers are required. GATA binding protein 3 (GATA3) has been suggested as a diagnostic marker for sarcomatoid mesothelioma. The potential usefulness of GATA3 for prognostication and its clinical and pathological correlations in different subtypes of mesothelioma have not been evaluated. We investigated the immunohistochemical labeling and associations for GATA3, BRCA1-associated protein 1 (BAP1), and Ki67 labeling in three major histological types of pleural malignant mesotheliomas. We examined 149 clinically annotated malignant mesotheliomas and assessed associations of GATA3 expression with clinical variables and prognosis. In addition, we labeled 10 cases of fibrous pleuritis with GATA3, all of which were negative. GATA3 was positive in 75 of 149 (50%) mesotheliomas, with the highest incidence of labeling seen in the sarcomatoid subtype (73%), compared with the biphasic (50%) and epithelioid (40%), mesotheliomas. A total of eight desmoplastic mesotheliomas showed labeling with GATA3. Patients whose tumors had sarcomatoid histology showed poorer survival than those with the other subtypes (p < 0.001), but overall GATA3 labeling did not have a statistically significant association with survival (p = 0.602). There was no association of GATA3 labeling and BAP1 status or Ki67 index. Our study includes the largest cohort of mesotheliomas that has been labeled for GATA3 to date. GATA3 is a useful marker for sarcomatoid mesothelioma, including the desmoplastic subtype. Discordance in GATA3 and BAP1 labeling of epithelioid and sarcomatoid components in the biphasic subtype is not uncommon.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Female
Humans
Ki-67 Antigen analysis
Male
Mesothelioma, Malignant mortality
Mesothelioma, Malignant pathology
Mesothelioma, Malignant therapy
Middle Aged
Pleural Neoplasms mortality
Pleural Neoplasms pathology
Pleural Neoplasms therapy
Predictive Value of Tests
Prognosis
Tumor Suppressor Proteins analysis
Ubiquitin Thiolesterase analysis
Biomarkers, Tumor analysis
GATA3 Transcription Factor analysis
Immunohistochemistry
Mesothelioma, Malignant chemistry
Pleural Neoplasms chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 105
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 32888937
- Full Text :
- https://doi.org/10.1016/j.humpath.2020.08.005