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Quantitative phylogenomic evidence reveals a spatially structured SARS-CoV-2 diversity.
- Source :
-
Virology [Virology] 2020 Nov; Vol. 550, pp. 70-77. Date of Electronic Publication: 2020 Aug 26. - Publication Year :
- 2020
-
Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent RNA virus that spread around the planet in about 4 months. The consequences of this rapid dispersion are under investigation. In this work, we analyzed thousands of genomes and protein sequences from Africa, America, Asia, Europe, and Oceania. We provide statistically significant evidence that SARS-CoV-2 phylogeny is spatially structured. Remarkably, the virus phylogeographic patterns were correlated with ancestral amino acidic substitutions, suggesting that such mutations emerged along colonization events. We hypothesize that geographic structuring is the result of founder effects occurring as a consequence of, and local evolution occurring after, long-distance dispersion. Based on previous studies, the possibility that this could significantly affect the virus biology is not remote.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Africa epidemiology
Americas epidemiology
Asia epidemiology
Betacoronavirus classification
Betacoronavirus genetics
COVID-19
Coronavirus Infections diagnosis
Europe epidemiology
Evolution, Molecular
Humans
Oceania epidemiology
Open Reading Frames
Pandemics
Phylogeny
Phylogeography
Pneumonia, Viral diagnosis
SARS-CoV-2
Viral Proteins genetics
Betacoronavirus pathogenicity
Coronavirus Infections epidemiology
Coronavirus Infections transmission
Disease Outbreaks
Genetic Variation
Genome, Viral
Pneumonia, Viral epidemiology
Pneumonia, Viral transmission
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0341
- Volume :
- 550
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 32890979
- Full Text :
- https://doi.org/10.1016/j.virol.2020.08.010