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Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2020 Oct; Vol. 103, pp. 104223. Date of Electronic Publication: 2020 Aug 26. - Publication Year :
- 2020
-
Abstract
- Seven new cembrane-type diterpenes, lobophytolins C-I (3-9), and one new prenylated-guiane-type diterpene, lobophytolin J (10), along with six known related ones (1, 2, 11-14), have been isolated from the soft coral Lobophytum sp. collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis and quantum mechanical (QM)-NMR methods. The absolute configuration of lobophytolin H (8) was determined by the application of the modified Mosher's method and chemical transformation. Lobophytolin D (4) exhibited promising cytotoxicities in in vitro bioassays against HT-29, Capan-1, A549, and SNU-398 human cancer cell lines with IC <subscript>50</subscript> values of 4.52, 6.62, 5.17, and 6.15 μM, respectively.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Cell Line, Tumor
Diterpenes chemistry
Diterpenes isolation & purification
Drug Screening Assays, Antitumor
Humans
Stereoisomerism
Anthozoa chemistry
Antineoplastic Agents pharmacology
Diterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 103
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32891002
- Full Text :
- https://doi.org/10.1016/j.bioorg.2020.104223